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Calcium is a mineral that is found naturally in foods. Calcium is necessary for many normal functions of your body, especially bone formation and maintenance. Calcium can also bind to other minerals (such as phosphate) and aid in their removal from the body. Calcium citrate is used to prevent and to treat calcium deficiencies. Calcium citrate may also be used for other purposes not listed in this medication guide.
Cholecalciferol is a Vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body. Cholecalciferol is used to treat or prevent many conditions caused by a lack of vitamin D, especially conditions of the skin or bones. Cholecalciferol may also be used for purposes not listed in this medication guide.
Zinc is a naturally occurring mineral. Zinc is important for growth and for the development and health of body tissues. Zinc sulfate is used to treat and to prevent zinc deficiency
Magnesium hydroxide is an antacid. It works by neutralizing the acid in the stomach and by stimulating the bowels to move
The major mechanism whereby calcium effects bone is through inhibition of PTH secretion. Calcium alters the physicalchemical properties of the bone mineral. With inadequate calcium, the bone is not optimally mineralized. Direct effects of calcium on the calcium receptor could also play a role. Magnesium plays an essential role in the proper functioning of the nerves, muscles and heart. It plays an important role in uterine muscle tone during pregnancy and labor. Zinc helps your immune system and plays a role in making DNA and proteins. It is required for the functioning of enzymes that produce collagen and other connective proteins needed for bone matrix. Zinc deficiency is linked to poor bone growth. Vitamin D must be adequate for optimal absorption of calcium.
Absorption: Calcium – Approx 33% of oral calcium absorbed via active transport & passive diffusion in small intestine. Vitamin D3- Well absorbed from GIT.
Distribution: Calcium- Skeletal tissue, breast milk. Crosses placenta. Vitamin D3- Vitamin D & metabolites binds to vitamin. D binding protein & are circulated in blood. May be store in adipose & muscle tissue for prolonged period.
Metabolism: Calcium citrate- Calcium citrate is a readily digested & absorbed form of calcium. Vitamin D3- Hydroxylate Vitamin D in liver to form 25-hydroxycholecalciferol then hydroxylated in kidney to form active metabolites 1/25-dihyroxycholecalciferol.
Excretion: Calcium- Unabsorbed calcium mainly excreted via faeces. Excess absorbed calcium excreted via urine. Vitamin D3- Vitamin D is mainly excreted in bile & faeces. Common side effects:
